I’m calling this photo a Bunsen Byrner

Recently I was lucky enough to get an invite to the 11th CaRLa Catalysis Winter School in Heidelberg, and it was an eye-opening and engaging week, meeting with some of the rising talents within the fields of homogenous catalysis (among others) and hearing from speakers like Mats Tilset (check out his recent article on trans-mutation of gold – a pun I really approve of) and Ilan Marek about their contributions to the field. In particular, I enjoyed having a week to spend time discussing posters with the other attendees; normally this is the most rushed part of any conference, as you try to simultaneously stand by your own poster and see as many others as possible. The Winter School invited flash presentations on all the posters, and gave ample time and coffee over which to really get into the details!

CaRLa (The Catalysis Reasearch Laboratory) is an institute at University of Heidelberg, supported by BASF, a giant of the chemical industry. As a result, the research they undertake is very aligned to real economic and market challenges. We were given a tour of the massive site at Ludwigshafen on the river Rhine, and the scale of production in just the one plant we visited was staggering – round-bottom flasks just can’t compete with building-sized reactors!

One interesting historical note about Heidelberg is that it is where Robert Bunsen did much of his pioneering work in 19th century chemistry and – famously – gifting us with the most widely known (and least widely-used nowadays) apparatus of the chemistry lab. I couldn’t walk past his statue without getting a punny selfie- the “Bunsen Byrner”!


CASE 2015 on the Cover of Supramolecular Chemistry

It was great to read a comprehensive write-up of CASE2015 in Supramolecular Chemistry (http://dx.doi.org/10.1080/10610278.2016.1150595). I designed the website for this conference and helped out with logistics. Many of the photos that appear in the article were taken by me – great that they can be used to show the community how productive a few days it was.


Gunnlaugsson Group, Trinity College Dublin

img_7678 This month’s cover of Supramolecular Chemistry

This month’s issue of the Taylor & Francis journal Supramolecular Chemistry features a review on CASE 2015 by Robert Elmes, with a picture from the conference on the cover. CASE 2015  (Catalysis and Sensing for our Environment) was part-hosted in Trinity College Dublin, and organised by Thorri, along with Aisling Hume (TCD), Donal O’Shea (RCSI), and Robert Elmes (Maynooth).

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It was great news today to hear the 2016 Nobel Prize in Chemistry was awarded to some pioneers in the field of supramolecular chemistry: Jean-Pierre Sauvage, J Fraser Stoddart and Bernard Feringa. During my PhD studies, I read the work of Sauvage and Stoddart a lot for inspiration; they are constantly producinSauvage's article in Tetrahedron Letters 1983g beautiful and elegant structures from discrete molecular units interacting in controlled ways. While most of my PhD ended up focussing on lanthanide-directed self assembly and luminescent compounds, I was always chasing the goal of interlocked structures and remember being fascinated by Sauvage’s early results describing the first metal-directed catenanes (Tetrahedron Letters 1983), mechanically interlocked rings with no chemical bonds between the two molecular components. This article laid the groundwork for the tiny molecular machines for which the trio were given the prestigious award today. Stoddart’s contributions to controlling rotaxane movement and Feringa’s publication of the first ‘molecular motor’ were remarkable breakthroughs, but the elegance of interlocked systems has fascinated me since I first saw them and I was delighted to finally publish some of my own work on catenanes in Angewandte Chemie this year, contributing in a small way to the ever-expanding supramolecular field.

To end this post, I’ll add a quote from my PhD supervisor Prof Thorri Gunnlaugsson (Trinity College Dublin) talking today about Sir JF Stoddart, a man he greatly admires and who received an honorary doctorate from Trinity a few years ago:

Speaking about the significance of the work that led to him sharing the 2016 Nobel Prize, Professor of Chemistry at Trinity, Thorri Gunnlaugsson, said: This is truly a fantastic day for chemists and specially for those of us who are involved in the development of supramolecular and nano-chemistry. The development of molecules that are functional and can carry out actions such as programmed operations, and can mimic macroscopic function on the nanoscale, such as that of machines, has been at the heart of this area of chemistry.”

“Today’s announcement of the Nobel Prize in Chemistry being awarded to Professors Stoddart, Sauvage and Feringa, for their development of molecular machines, acknowledges the major scientific achievement made to date in this important field.”



“Captured and put in chains” – new article in Angewandte Chemie

“Captured and put in chains” – new article in Angewandte Chemie

I recently finished working in Trinity College Dublin after five and a half productive years. My final project was completed in the weeks before I left and submitted to the prestigious journal Angewandte Chemie on the 1st April, the day I started in my new position at Universität Bern.

This article has just come out, and I’m rather proud of it, and happy that it is a fitting ending to my time in Dublin. My original goal in Thorri Gunnlaugsson’s research groupwas to form interlocked molecules, such as “catenanes”, but this challenging goal kept moving further down the queue as we discovered new and interesting ways to exploit the “btp” motif (which has been the topic of all my research to date). But finally, and somewhat unexpectedly, we achieved this goal.

Creating these new structures built upon interesting behaviour we reported in our Chemistry – A European Journal article early this year – where we saw that btp molecules could interact with each other, forming pairs through weak hydrogen bonding. We wondered if this could be used to pre-organise molecules together in such a way that they could be ‘clipped’ together into interlocked rings (by “RCM”, as outlined in the Scheme above). This approach has occasionally been reported before for amides,but not for molecules like the ones we describe.

A representation of the formation of catenanes from btp ligands

In fact, this reaction was more successful than expected – and in the first case I tried, we were surprised to find the majority product (50% yield) was the interlocked “catenane”, with independent non-interlocked rings also observed. We were able to fully identify and characterise these molecules using X-ray crystallographic analysis, giving the clear pictures below (thanks to Dr Salvador Blasco).

These were nice structures, but I wanted them to do something more than look pretty! Discussions with my friend Anna Aletti opened up the idea that the cavity in the middle of the structures might be a perfect fit for some negatively charged ion guest, such as chloride, nitrate or sulfate – none of these ions did very much, but phosphate (the tetrahedral H2PO4- ion), on the other hand, caused changes in the “catenane” host, indicating specific interactions between these two molecules. This was exciting. It makes these the first catenanes in the literature to have such interactions with tetrahedral anions.

The catenane acts as a selective host for phosphate, as can be seen from changes in the NMR spectrum

Detailed analysis of the formation of these interesting compounds, as well as their adducts with phosphate was important to strengthening these results and making sure we understood what we were seeing. Working closely with Dr Gary Hessman, Technical Officer at TCD, allowed further insight into the systems and their composition.

If any of this sounds interesting, then you should read the article (http://dx.doi.org/10.1002/anie.201603213) or at least look at the pictures! One fun advantage of publishing in Angewandte Chemie is that they translate your abstract into German (which I am currently learning), which means I now know the useful everyday term “Triazolylwasserstoffbrüken“, which – of course – means “triazolyl hydrogen-bonding interactions”. I now use that in the pubs of Bern almost daily!

TG Group travel to Southampton for Supramolecular Symposium

It was nice to catch up with some old colleagues in Southampton and chat molecular logic with my “academic grandfather” AP de Silva, as well as why he enjoyed being educated by Buddhist monks and Catholic nuns at the same time in Sri Lanka!

Gunnlaugsson Group, Trinity College Dublin

Anna Aletti, Samuel Bradberry and Dr. Oxana Kotova of the TG group attended Southampton Supramolecular Chemistry Symposium on the 24th of June 2016.

delegates Southamption Supramolecular Symposium 2016 Delegates

All of them presented posters and, in addition, Samuel gave an excellent talk on “Lanthanide Luminescent Logic – functional organic scaffolds and soft polymers gels as logic gate mimics”.

DSC_0048 Sam giving his talk

DSC_0036 Sam and A P at the poster session

DSC_0043 Oxana with her poster

DSC_0035 Anna presenting her poster

2016-06-24 18.02.36 A P de Silva, Oxana, Anna, Joe and Sam at the drinks reception

Our former group member Dr. Joseph Byrne who is currently a postdoctoral researcher in the University of Bern attended the conference as well and presented a poster on his recent work published in Angew. Chem. Int. Ed. on self-templated btp [2]Catenane.

The meeting included speakers and posters from UK Universities and beyond, including an outstanding lecture from the…

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Collaborations in Hong Kong

Collaborations in Hong Kong

I had the pleasure of spending some time this month in Hong Kong University in the laboratory of Professor Vivian Wing-Wah Yam, a high-profile inorganic chemist. We had previously had conversations about some overlap in our research interests and, thanks to the generous support of Science Foundation Ireland’s “International Strategic Collaboration Programme for China“, I was able to visit HKU and begin collaborative work, investigating luminescent inorganic compounds. I am also very grateful for the support of my supervisor Professor Thorri Gunnlaugsson in encouraging this endeavour and Professor Yam and her group for their hospitality: I ate the best authentic Cantonese food for lunch all through my stay!

Dr Sammual Yu-Lut Leung was exceptionally generous with his time during
my visit, arranging an office for me and teaching me some new techniques in the laboratory. The work we carried out during my visit will form the foundations for an exciting project.

I was invited to give a research seminar to members of the Chemistry Department in HKU on Friday 11th December 2015 and was delighted to have the opportunity to share my work with researchers so far geographically from home and discuss it in detail afterwards.

I gave a seminar on my research to researchers in HKU while visiting

Hong Kong is a beautiful city, a real melting pot of cultures, cuisine and indeed science. I immensely enjoyed my time there and believe this trip was the start of something fruitful.