Swiss Chemical Society Fall Meeting

A large contingent from the Albrecht research group in Bern made our way down to Lausanne today for the Swiss Chemical Society’s annual Fall Meeting at EPFL. As always, it was a massive meeting, underscoring the impressive amount of chemistry research that goes on in small-but-mighty Switzerland.

The introductory speaker, Prof Emsley, highlighted some unique aspects of Swiss research, including the strong industrial presence in the country (indicated by the generous sponsorship of every session by pharmaceutical and instrumentation companies), as well as the rich international complexion of the researchers who work at the Swiss Universities and companies. More than a quarter of all researchers are non-nationals – and that is a real strength, allowing for diverse workers and ideas to come together from all over Europe and the world. Mobility and openness, in principle, allow the best people to find the best partners for their research and push forward important developments in science.

One of my colleagues presented his recent results (Angewandte Chemie), while seven of us presented posters over the extended lunchtime session. Lots of interesting conversations were had with researchers at other universities, as well as industrial chemists; in Switzerland industrial chemists are well integrated into the professional society (the SCS), which I think is beneficial to all of us, for focussing our targets and sharing the latest advances. Indeed, in addition to leading academics like Prof Karsten Meyer, we also saw presentations from the likes of Syngenta.

We got to socialise a little and explore the EPFL campus after the talks, and, in the Rolex Building, I was lucky enough to run into old friend Marie Curie! I had a colleague snap this photo of me and the other Marie Sklowdowska-Curie Fellow in the Albrecht group with our mentor! She’s everywhere!

Marie Curie and her fellows

 

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Chemistry in the Rising Sun – ICCC in Sendai

Pictures of me presenting at ICCC in SendaiI am just after returning from the 43 (and largest ever) International Conference of  coordintion Chemistry in Sendai, Japan. This year’s ICCC had an awful lot to offer, with 2,500 of us in the Sendai International Centre, and spread over up to twenty parallel session at times, there is clearly a lot happening in inorganic and coordination at the moment. Some highlights included fascinating molecular machines (with an inspiring closing address from 2016 Nobel laureate Jean-Pierre Sauvage), catalytic approaches to the challenges presented by the need to find new fuel sources for a changing world, new pincer and NHC ligands, luminescent diagnostic probes and therapeutic agents and much much more.

Me speaking from the podium in the Exhibition Hall on Thursday morning

I was privileged to get the chance to present my work in Session 38 “Organometallic complexes for synthesis and polymerisation”, to a room full of my peers and leaders in the field, including people I had interacted with during the week and who came along to see what it is I am up to in my current work! My presentation on the catalytic activity of carbohydrate-functionalised N-heterocyclic carbene complexes went very well and there were even a few useful questions that prompted a bit of discussion afterwards.

After Thursday morning, I could relax a bit more and just enjoy attending the sessions without worrying about perfecting my talk! Luckily that afternoon had also been set aside on the programme for sight-seeing, so I wandered around the site of Sendai Castle and the adjacent shrine with a few other chemists. I also got to sample the regional delicacy of beef tongue and make my own chopsticks from scratch. A nice mix of learning, culture and networking.

 

I really enjoyed catching up with old colleagues from Europe and the UK and meeting new people from both hemispheres to share ideas with (as well as a fateful trip to karaoke after the conference banquet wrapped up earlier than necessary) as well as the engaging discussions had at the poster sessions. I’m also getting better at asking questions after lectures, as my confidence in the field grows with experience!

Looking forward to the next one in Rimini!

Thanks, of course, to my Marie Skłodowska Curie Fellowship (GLYCONHC) and the European Commission for funding the work which I presented

I’m calling this photo a Bunsen Byrner

Recently I was lucky enough to get an invite to the 11th CaRLa Catalysis Winter School in Heidelberg, and it was an eye-opening and engaging week, meeting with some of the rising talents within the fields of homogenous catalysis (among others) and hearing from speakers like Mats Tilset (check out his recent article on trans-mutation of gold – a pun I really approve of) and Ilan Marek about their contributions to the field. In particular, I enjoyed having a week to spend time discussing posters with the other attendees; normally this is the most rushed part of any conference, as you try to simultaneously stand by your own poster and see as many others as possible. The Winter School invited flash presentations on all the posters, and gave ample time and coffee over which to really get into the details!

CaRLa (The Catalysis Reasearch Laboratory) is an institute at University of Heidelberg, supported by BASF, a giant of the chemical industry. As a result, the research they undertake is very aligned to real economic and market challenges. We were given a tour of the massive site at Ludwigshafen on the river Rhine, and the scale of production in just the one plant we visited was staggering – round-bottom flasks just can’t compete with building-sized reactors!

One interesting historical note about Heidelberg is that it is where Robert Bunsen did much of his pioneering work in 19th century chemistry and – famously – gifting us with the most widely known (and least widely-used nowadays) apparatus of the chemistry lab. I couldn’t walk past his statue without getting a punny selfie- the “Bunsen Byrner”!

CASE 2015 on the Cover of Supramolecular Chemistry

It was great to read a comprehensive write-up of CASE2015 in Supramolecular Chemistry (http://dx.doi.org/10.1080/10610278.2016.1150595). I designed the website for this conference and helped out with logistics. Many of the photos that appear in the article were taken by me – great that they can be used to show the community how productive a few days it was.

CASE2015.PNG

Gunnlaugsson Group, Trinity College Dublin

img_7678 This month’s cover of Supramolecular Chemistry

This month’s issue of the Taylor & Francis journal Supramolecular Chemistry features a review on CASE 2015 by Robert Elmes, with a picture from the conference on the cover. CASE 2015  (Catalysis and Sensing for our Environment) was part-hosted in Trinity College Dublin, and organised by Thorri, along with Aisling Hume (TCD), Donal O’Shea (RCSI), and Robert Elmes (Maynooth).

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It was great news today to hear the 2016 Nobel Prize in Chemistry was awarded to some pioneers in the field of supramolecular chemistry: Jean-Pierre Sauvage, J Fraser Stoddart and Bernard Feringa. During my PhD studies, I read the work of Sauvage and Stoddart a lot for inspiration; they are constantly producinSauvage's article in Tetrahedron Letters 1983g beautiful and elegant structures from discrete molecular units interacting in controlled ways. While most of my PhD ended up focussing on lanthanide-directed self assembly and luminescent compounds, I was always chasing the goal of interlocked structures and remember being fascinated by Sauvage’s early results describing the first metal-directed catenanes (Tetrahedron Letters 1983), mechanically interlocked rings with no chemical bonds between the two molecular components. This article laid the groundwork for the tiny molecular machines for which the trio were given the prestigious award today. Stoddart’s contributions to controlling rotaxane movement and Feringa’s publication of the first ‘molecular motor’ were remarkable breakthroughs, but the elegance of interlocked systems has fascinated me since I first saw them and I was delighted to finally publish some of my own work on catenanes in Angewandte Chemie this year, contributing in a small way to the ever-expanding supramolecular field.

To end this post, I’ll add a quote from my PhD supervisor Prof Thorri Gunnlaugsson (Trinity College Dublin) talking today about Sir JF Stoddart, a man he greatly admires and who received an honorary doctorate from Trinity a few years ago:

Speaking about the significance of the work that led to him sharing the 2016 Nobel Prize, Professor of Chemistry at Trinity, Thorri Gunnlaugsson, said: This is truly a fantastic day for chemists and specially for those of us who are involved in the development of supramolecular and nano-chemistry. The development of molecules that are functional and can carry out actions such as programmed operations, and can mimic macroscopic function on the nanoscale, such as that of machines, has been at the heart of this area of chemistry.”

“Today’s announcement of the Nobel Prize in Chemistry being awarded to Professors Stoddart, Sauvage and Feringa, for their development of molecular machines, acknowledges the major scientific achievement made to date in this important field.”

 

 

“Captured and put in chains” – new article in Angewandte Chemie

“Captured and put in chains” – new article in Angewandte Chemie

I recently finished working in Trinity College Dublin after five and a half productive years. My final project was completed in the weeks before I left and submitted to the prestigious journal Angewandte Chemie on the 1st April, the day I started in my new position at Universität Bern.

This article has just come out, and I’m rather proud of it, and happy that it is a fitting ending to my time in Dublin. My original goal in Thorri Gunnlaugsson’s research groupwas to form interlocked molecules, such as “catenanes”, but this challenging goal kept moving further down the queue as we discovered new and interesting ways to exploit the “btp” motif (which has been the topic of all my research to date). But finally, and somewhat unexpectedly, we achieved this goal.

Creating these new structures built upon interesting behaviour we reported in our Chemistry – A European Journal article early this year – where we saw that btp molecules could interact with each other, forming pairs through weak hydrogen bonding. We wondered if this could be used to pre-organise molecules together in such a way that they could be ‘clipped’ together into interlocked rings (by “RCM”, as outlined in the Scheme above). This approach has occasionally been reported before for amides,but not for molecules like the ones we describe.

A representation of the formation of catenanes from btp ligands

In fact, this reaction was more successful than expected – and in the first case I tried, we were surprised to find the majority product (50% yield) was the interlocked “catenane”, with independent non-interlocked rings also observed. We were able to fully identify and characterise these molecules using X-ray crystallographic analysis, giving the clear pictures below (thanks to Dr Salvador Blasco).

These were nice structures, but I wanted them to do something more than look pretty! Discussions with my friend Anna Aletti opened up the idea that the cavity in the middle of the structures might be a perfect fit for some negatively charged ion guest, such as chloride, nitrate or sulfate – none of these ions did very much, but phosphate (the tetrahedral H2PO4- ion), on the other hand, caused changes in the “catenane” host, indicating specific interactions between these two molecules. This was exciting. It makes these the first catenanes in the literature to have such interactions with tetrahedral anions.

The catenane acts as a selective host for phosphate, as can be seen from changes in the NMR spectrum

Detailed analysis of the formation of these interesting compounds, as well as their adducts with phosphate was important to strengthening these results and making sure we understood what we were seeing. Working closely with Dr Gary Hessman, Technical Officer at TCD, allowed further insight into the systems and their composition.

If any of this sounds interesting, then you should read the article (http://dx.doi.org/10.1002/anie.201603213) or at least look at the pictures! One fun advantage of publishing in Angewandte Chemie is that they translate your abstract into German (which I am currently learning), which means I now know the useful everyday term “Triazolylwasserstoffbrüken“, which – of course – means “triazolyl hydrogen-bonding interactions”. I now use that in the pubs of Bern almost daily!

TG Group travel to Southampton for Supramolecular Symposium

It was nice to catch up with some old colleagues in Southampton and chat molecular logic with my “academic grandfather” AP de Silva, as well as why he enjoyed being educated by Buddhist monks and Catholic nuns at the same time in Sri Lanka!

Gunnlaugsson Group, Trinity College Dublin

Anna Aletti, Samuel Bradberry and Dr. Oxana Kotova of the TG group attended Southampton Supramolecular Chemistry Symposium on the 24th of June 2016.

delegates Southamption Supramolecular Symposium 2016 Delegates

All of them presented posters and, in addition, Samuel gave an excellent talk on “Lanthanide Luminescent Logic – functional organic scaffolds and soft polymers gels as logic gate mimics”.

DSC_0048 Sam giving his talk

DSC_0036 Sam and A P at the poster session

DSC_0043 Oxana with her poster

DSC_0035 Anna presenting her poster

2016-06-24 18.02.36 A P de Silva, Oxana, Anna, Joe and Sam at the drinks reception

Our former group member Dr. Joseph Byrne who is currently a postdoctoral researcher in the University of Bern attended the conference as well and presented a poster on his recent work published in Angew. Chem. Int. Ed. on self-templated btp [2]Catenane.

The meeting included speakers and posters from UK Universities and beyond, including an outstanding lecture from the…

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