I’m delighted to finally publish this work, the first of my research carried out during my Marie Curie Fellowship in University of Bern to come out. A lot of hard work by Erasmus student Pauline went into gathering data behind this manuscript where we asked the question – what impact would incorporating carbohydrates into the structure of a Ruthenium(II)-triazolylidene complex have on its ability to convert a ketone to an alcohol via transfer hydrogenation catalysis.
There were challenges in isolating the desired compound, so it had to be generated in situ, but we were able to assess the activity, and the results were interesting, and can be found in detail here in Dalton Transactions.
To summarise the conclusions: The carbohydrate functionality does impact catalytic activity (transfer hydrogenation of ketones). In complexes with the glucose directly triazolylidene-bound, turnover rates were substantially higher when compared to more remote carbohydrate functionalisation (i.e. with an ethylene spacer). Both new complexes, however, have reduced activity compared to unfunctionalised carbene complexes. Insight was also gained into the nature of the catalytic cycle through a substrate scope analysis.
This month’s cover of Supramolecular Chemistry
Time to Byrne 